Yoshio Kuwayama Selected Research

Acute Eosinophilic Leukemia

9/2007

AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.

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Yoshio Kuwayama Research Topics

Disease

5	Neoplasms (Cancer) 01/2014 - 06/2007
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2014 - 06/2007
4	Leukemia 05/2008 - 05/2007
2	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 02/2008 - 05/2007
1	Infections 01/2014
1	Hypercalcemia (Milk Alkali Syndrome) 01/2014
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2012
1	Papilloma (Papillomatosis) 01/2012
1	Hemorrhage 06/2011
1	Hypereosinophilic Syndrome (Loeffler Endocarditis) 05/2008
1	Acute Eosinophilic Leukemia 09/2007
1	Blast Crisis (Blast Phase) 09/2007
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 09/2007
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 09/2007
1	Carcinogenesis 06/2007
1	Aneuploidy (Aneuploid) 06/2007
1	Eosinophilia 01/2007
1	Thrombosis (Thrombus) 01/2007
1	Abdominal Pain (Pain, Abdominal) 02/2002

Drug/Important Bio-Agent (IBA)

2	Proteins (Proteins, Gene)FDA Link 01/2014 - 05/2008
2	Aurora KinasesIBA 09/2007 - 06/2007
2	ThymidineIBA 09/2007 - 06/2007
2	Phosphotransferases (Kinase)IBA 09/2007 - 06/2007
1	Messenger RNA (mRNA)IBA 01/2014
1	Calcitriol (Calcijex)FDA LinkGeneric 01/2014
1	Apoptosis Regulatory ProteinsIBA 01/2012
1	CarcinogensIBA 01/2012
1	Lenalidomide (CC 5013)FDA Link 06/2011
1	fms-Like Tyrosine Kinase 3IBA 05/2008
1	Platelet-Derived Growth Factor alpha ReceptorIBA 05/2008
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 05/2008
1	Ki11502IBA 05/2008
1	Imatinib Mesylate (Gleevec)FDA Link 05/2008
1	NF-kappa B (NF-kB)IBA 02/2008
1	4- (4- (N- benzoylamino)anilino)- 6- methoxy- 7- (3- (1- morpholino)propoxy)quinazolineIBA 09/2007
1	2- ((3- ((4- ((5- (2- ((3- fluorophenyl)amino)- 2- oxoethyl)- 1H- pyrazol- 3- yl)amino)quinazolin- 7- yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphateIBA 09/2007
1	TubulinIBA 09/2007
1	Topoisomerase II InhibitorsIBA 09/2007
1	Aurora Kinase BIBA 09/2007
1	Aurora Kinase AIBA 06/2007
1	Annexin A5IBA 06/2007
1	DNA (Deoxyribonucleic Acid)IBA 06/2007
1	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA 05/2007
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 05/2007
1	TOR Serine-Threonine KinasesIBA 05/2007
1	Sirolimus (Rapamycin)FDA Link 05/2007
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2007
1	Hemoglobins (Hemoglobin)IBA 02/2002

Therapy/Procedure

2	Therapeutics 01/2012 - 01/2007
1	Induction Chemotherapy 01/2014